For non-exempt projects, if anything about your protocol changes (such as personnel, location, number of participants, procedures, etc.), you must obtain IRB approval of those changes prior to implementation unless they are necessary to eliminate apparent immediate hazards to the subject. You should complete the modification in the myProtocol system for review.
For projects granted an Exempt Determination, further oversight by the HRPP is not required. Therefore, when an exemption has been granted, the HRPP will inactivate that study in the myProtocol system. While the study has been inactivated, it means that recruitment, enrollment, data collection, and/or data analysis can continue, but personnel and procedural amendments to the study are no longer required. However, if at any point the risk to participants increases, you must contact the HRPP immediately with that information to see if an amendment is required.